|Molecular Weight||318.13 g/mol|
|Synonyms||2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium|
|Appearance||White to almost white solid|
|Storage Temperature||Room temperature|
|Applications||Diclofenac Impurity 21 (Diclofenac Sodium) is a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Oxidation of diclofenac sodium produces the metabolite 4′-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4′-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.|
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